Idiotype Expression in Precursors of Myeloma Cells
نویسندگان
چکیده
From the Cellular Immunobiology Unit of the Tumor Institute, Departments of Pediatrics, Medicine and Microbiology, The Comprehensive Cancer Center, University of Alabama in Birmingham, Birmingham, Alabama 35294; and the Department of Microbiology, Southwestern Medical School, Graduate School of Biomedical Sciences, School of Allied Health Sciences University of Texas Health Science Center at Dallas, Dallas, Texas 75235
منابع مشابه
Cellular basis of regulation of expression of idiotype. I. T-suppressor cells specific for MOPC 460 idiotype regulate the expression of cells secreting anti-TNP antibodies bearing 460 idiotype
An idiotype of the dinitrophenyl-binding myeloma protein MOPC 460 was expressed on a small but significant proportion of anti-TNP antibodies which appeared after in vivo or in vitro immunization of BALB/c mice with three T-independent TNP antigens. In vitro experiments show that the depletion of T cells before culture increased significantly the number of plaques secreting anti-TNP antibodies b...
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IgA myeloma proteins of kappa- and lambda-types were isolated from two patients. These were used to produce and purify anti-idiotype antibodies of both broad (myeloma-related) and narrow (individual myeloma) specificities. The anti-idiotype antibodies were conjugated with fluorochromes and used as immunofluorescent probes to trace in the patients clonal expansion at different levels of B-cell d...
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BALB/c mice immunized with bacterial levan (BL) produce a vigorous antibody response that fails to include antibodies expressing the idiotype of the beta 2 leads to 6 fructosan-binding myeloma protein ABPC48 (A48). Treatment of newborn BALB/c mice at 1 d of age with 0.1-10 microgram of either the A48 myeloma protein or monoclonal proteins that share idiotopes with the A48 family, followed by im...
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In this issue of Clinical Cancer Research , Hansson et al. vaccinated 28 patients (IgG myeloma, Salmon-Durie stages I and II) with autologous myeloma idiotype protein and assessed the effect of adding either granulocyte macrophage colonystimulating factor (GM-CSF) alone or the combination of GMCSF and interleukin 12 (IL-12) during the vaccination program (1). Idiotype-specific T-cell responses ...
متن کاملCD93 is Selectively Expressed on Human Myeloma Cells but Not on B Lymphocytes
Background: CD93 has originally been known as a C1q receptor, and many studies have demonstrated that CD93 is expressed on hematopoietic stem cells, B cell progenitors, myeloid and monocytic cells. Moreover, CD93 is shown to be expressed on long-lived plasma cells, and CD93 deficient-mice display an impairment in plasma cell development. Objective: To investiga...
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تاریخ انتشار 2003